I recently had to load balance our Exchange SMTP Relay and IIS SMTP Relay. Both of these require the use of DSR which I was unfamiliar with and wanted to share my experience.
Read this if DSR and Netscaler isn't working for you
As per the comment from rbarrick on the above article, I also found the same problem. I had more than one VIP with the same IP and even though they were disabled it would not connect until I deleted the disabled Virtual Servers with the same IP. I had them setup after following this article on Exchange Load balancing so when it came to configuring DSR I had multiple VIP's with the same IP. Deleting them or changing the IP they use is the only solution. Hope this saves someone some head scratching.
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